2026년도 4월 세미나 안내- UCB

안녕하세요 KOLIS 회원 여러분,

아래와 같이 4 월 세미나가 준비되어 여러분께 공지드리고자 합니다.

(RSVP후 참여하시는 분들께는 기프트카드를 제공할 예정입니다!)

해당 세미나는 hybrid (in-person + zoom)으로 진행될 예정이며, 세미나 이후 네트워킹 시간을 가질 계획입니다.

감사합니다.

- KOLIS 2026 운영진 드림

• 연사: J. Wren Kim, PhD

• 시간: 4월 27일 (월) 오후 3시 (PT)

• 장소: 100D (seminar room D) Hildebrand Library

  https://maps.app.goo.gl/9xUcQ8Us3oXNMJZGA

• Zoom:

  https://berkeley.zoom.us/j/95448793866?pwd=F0tSesfqBLGPWc0bqk12OyB7QPnp10.1

• RSVP: https://forms.gle/na7rre2am3Vkc3zy7

• 제목: Gene Expression Programs Underlying Synchronous Network Activity

• Abstract:

  Neurons commonly fire in synchrony, a phenomenon critical for cognitive function. This coordinated firing requires activity-dependent fine-tuning of neuronal connectivity and excitability, processes in which gene expression plays a central role. However, the gene expression programs that support coordinated firing remain largely unknown. To address this, we developed CalTRAP-seq, a method for profiling gene expression in active neurons via calcium-dependent ribosome tagging. Applying CalTRAP-seq to active neuronal networks revealed distinct gene expression patterns associated with spontaneous and synchronous network activity, characterized by extensive regulation of neuronal excitability. Furthermore, we found that neuronal activity promotes nuclear speckle formation and changes alternative splicing of numerous synaptic genes. Disrupting nuclear speckles impaired the dynamics of network activity. Together, these findings identify a novel gene expression program linked to spontaneous network activity, providing new insight into how neurons regulate gene expression to support coherent network function.